the mechanisms of radiation-induced bystander effect
نویسندگان
چکیده
the radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. these changes are confirmed by results of some in-vivo studies. most well-known important factors affecting radiation-induced bystander effect include free radicals, immune system factors, expression changes of some genes involved in inflammation pathway and epigenetic factors.
منابع مشابه
The Mechanisms of Radiation-Induced Bystander Effect
The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo s...
متن کاملThe Mechanisms of Radiation-Induced Bystander Effect
The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo s...
متن کاملRadiation Induced Bystander Effect
Introduction: Radiation effects observed in cells that are not irradiated are known as non-targeted effects. Radiation induced bystander effect (RIBE) as a kind of non-targeted effect has been introduced in recent years. RIBE occurs in unexposed cells which are related to adjacent or distant irradiated cells. RIBE contradict with "target theory" which necessitates radiation tr...
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Objective Since most reports on bystander effect have been only concerned with radiation-induced damage, the present paper aimed at disclosing whether low dose radiation could induce a stimulatory or beneficial bystander effect. Methods A co-culture system containing irradiated antigen presenting cells (J774A.1) and unirradiated T lymphocytes (EL-4) was established to observe the effect of J774...
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There remains a need to improve our understanding of the hazards that arise through occupational and environmental exposures to ionizing radiations. An important aspect of this is the role of non-targeted effects (such as the bystander effect) in the biological response to low dose exposures. Micro-irradiation techniques have become an important method for radiobiolical studies of low-dose effe...
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A bystander effect is biological changes in non-irradiated cells by transmitted signals from irradiated bystander cells, which causes the radiation toxic effects on the adjacent non-irradiated tissues. This phenomenon occurs by agents such as ionizing radiation, ultraviolet radiation (UVR) and chemotherapy. The bystander effect includes biological processes such as damage to DNA, cell death, ch...
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عنوان ژورنال:
journal of biomedical physics and engineeringجلد ۴، شماره ۴ DEC، صفحات ۰-۰
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